David P. Labb茅 (PhD)
Associate Professor - Department of Surgery听
Ph.D., agr., chm.听
Currently supervising students
Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality, However, the molecular underpinnings of this association are poorly understood. My research program aims to understand the combination of key tumour genetic alterations together with the host characteristics required for diet to alter prostate cancer progression. This will allow the identification of new therapeutic targets and the elaboration of novel therapeutic approaches devised to treat prostate cancer patients at risk of progression to an aggressive, lethal disease. More specifically, my research focuses on the mechanisms and therapeutic targets related to epigenetic alterations, using murine and human cell lines, animal models (including genetically engineered mouse models) and human tissues.听
- Prostate cancer
- 狈耻迟谤颈迟颈辞苍/诲颈别迟听
- Impact of diet-induced obesity on prostate cancer chromatin remodeling.
- Role of diet in mediating prostate cancer genomic instability.
- Identification of key epigenetic-related genes responsible for prostate cancer aggressiveness.
EXSU 505听
Dr. David P. Labb茅 is an Associate Professor in the Department of Surgery, Division of Urology and a William Dawson Scholar at 海角社区 as well as a Prostate Cancer Foundation Young Investigator. Dr. Labb茅鈥檚 laboratory relies on high-throughput experiments, bioinformatics analyses, animal models and patient-derived tissues to discover the mechanisms by which diet affects the development and progression of prostate cancer. His overreaching goal is to leverage this information to identify both new therapeutic targets and approaches to improve and extend prostate cancer patients long-term health outcomes.听
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