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Dr. Cristian O'Flaherty

Academic title(s): 
  • Associate Professor - Department of Surgery聽
  • Associate Member - Department of Medicine聽
  • Associate Member - Department of Pharmacology and Therapeutics聽
Dr. Cristian O'Flaherty
Contact Information
Email address: 
cristian.oflaherty [at] mcgill.ca
Department: 
Surgery
Division: 
Urology
Degree(s): 

DVM, PhD聽

Location: 
海角社区 Health Centre (MUHC - Glen) - Royal Victoria Hospital
Graduate supervision: 

Currently supervising students

Group: 
Currently Recruiting
M.Sc. Students
M.Sc. Non-Thesis projects
Ph.D. Students
Research areas: 
Translation and Innovation
Current research: 

Male reproduction, oxidative stress, redox signaling聽

Areas of interest: 

  1. Redox signaling of sperm activation (motility, capacitation and acrosome reaction).聽

  1. Dysregulation of enzymatic antioxidant mechanisms in male infertility.聽

  1. Impact of oxidative stress in spermatogenesis and epididymal maturation.聽

  1. Role of redox-dependent protein modifications in sperm function.聽

  1. Regulation of testicular apoptosis.聽

  1. Regulation of survival pathways in spermatozoa.聽

  1. Male contraception.聽

  1. Novel diagnostic tools and therapies for male infertility.聽

Courses: 

EXSU 684聽

Biography: 

Dr. Cristian O鈥橣laherty is a professor in the Department of Surgery (Division of Urology) at 海角社区 and a medical scientist at the Research Institute of the 海角社区 Health Centre. He is also an associate member of the Departments of Pharmacology and Therapeutics, Anatomy and Cell Biology, and Experimental Medicine at 海角社区. Dr. O鈥橣laherty was Co-Director of the 海角社区 Centre for Research in Reproduction and Development during 2018-2021. He is an associate editor of Andrology, Human Reproduction, and Antioxidants Journal and a member of the Editorial Board of the Biology of Reproduction.聽

With a background in the biology of reproduction, he holds a D.V.M and Ph.D. in animal physiology and biochemistry degrees from the University of Buenos Aires, Argentina. He completed his postdoctoral studies in sperm physiology and toxicology at the Urology Division and the Department of Pharmacology and Therapeutics at 海角社区. He was awarded the Chercheur-boursier Junior 1 and 2 awards from the Fonds de la Recherche en Sant茅 du Qu茅bec (FRSQ), and his research program has been and is currently funded by different agencies, including the Canadian Institutes of Health Research, FRQS and the Fonds de Recherche Nature et technologies.聽

Dr. O鈥橣laherty鈥檚 research program focuses on male reproduction, particularly on the molecular mechanisms involved in the production and function of healthy spermatozoa and the role of reactive oxygen species (ROS) in sperm physiology and toxicology. Through mouse models and human spermatozoa, Dr. O鈥橣laherty aims to elucidate the role of the reactive oxygen species and antioxidant enzymes in regulating sperm function using genomic, proteomic and biochemical approaches. Dr. O鈥橣laherty was the first to identify the primary role of peroxiredoxin 6 in protecting the spermatozoa against oxidative stress and the participation of peroxiredoxins in regulating ROS during sperm capacitation. He is also dedicated to deciphering the molecular mechanisms that drive the spermatozoon to achieve the fertilizing ability to develop novel diagnostic and therapeutic strategies for male infertility.聽

Selected publications: 

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