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Benslimane Y, Amalfi K., Lapin S, Perrino S. and Brodt P. Estrogen receptor blockade potentiates immunotherapy for liver metastases by altering the liver immunosuppressive microenvironment. 2023, Submitted.

Preston S.E.J., Dahabieh M.S., Richard V.R., Leibovitch M., Gonçalves C., Dakin E., Huang F., Gagnon N., Perrino S., Zahedi R.P., Borchers C.H., Jones RG., Brodt P., Miller Jr. W.H. and del Rincón S.V. Targeting tumor-intrinsic MNK1 kinase restricts metabolic flexibility to diminish liver metastasis. 2023, In revision for Science Advances.

Chen Y.M, Chambon J., Moquin A., Hashimoto M., Perrino S., Leibovitch M., Benslimane Y., Gagné S. and Brodt P. Nanoparticle encapsulation enables systemic IGF-Trap delivery to inhibit intra-cerebral glioma growth. 2023, Neuro-Oncology, In revision

Chen Y.M., Leibovitch M., Zeinieh M., Jabado N. and Brodt P. Targeting the IGF-axis in cultured pediatric high-grade glioma cells inhibits cell cycle progression and survival. Pharamaceuticals (Basel). 2023 Feb 14;16(2):297. doi: 10.3390/ph16020297.

Latacz E, Höppener D, Bohlok A, Leduc S, Tabariès S, Fernández Moro C, Lugassy C, Nyström H, Bozóky B, Floris G, Geyer N, Brodt P, Llado L, Van Mileghem L, De Schepper M, Majeed AW, Lazaris A, Dirix P, Zhang Q, Petrillo SK, Vankerckhove S, Joye I, Meyer Y, Gregorieff A, Roig NR, Vidal-Vanaclocha F, Denis L, Oliveira RC, Metrakos P, Grünhagen DJ, Nagtegaal ID, Mollevi DG, Jarnagin WR, D'Angelica MI, Reynolds AR, Doukas M, Desmedt C, Dirix L, Donckier V, Siegel PM, Barnhill R, Gerling M, Verhoef C and Vermeulen PB. Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights, Br J Cancer. 2022 Oct;127(6):988-1013. doi: 10.1038/s41416-022-01859-7. Epub 2022 Jun 1.PMID: 35650276 Review.

Hashimoto M., Konda J.D., Perrino S., Fernandez M.C., Lowy A.M. and Brodt P. Targeting the IGF-axis potentiates immunotherapy for pancreatic ductal adenocarcinoma liver metastases by altering the immunosuppressive microenvironment. Mol Cancer Ther. 2021 Dec;20(12):2469-2482. doi: 10.1158/1535-7163. MCT-20-0144. Epub 2021 Sep 22.

Tsui J., Qi S., Perrino S., Leibovitch M., and Brodt P. Identification of a Resistance Mechanism to IGF-IR Targeting in Human Triple Negative MDA-MB-231 Breast Cancer Cells. Biomolecules 2021 Apr 1;11(4):527. doi: 10.3390/biom11040527

Tsilimigras D.I., Brodt P., Clavien P.A., Muschel R.J., D’Angelica MI., Endo I., Parks R.W., Doyle M., de Santibanes E., and Pawlik T.M. Liver Metastases. Nature Reviews: Disease Primers 2021 Apr 15;7(1):27. doi: 10.1038/s41572-021-00261-6

Samani A.A., Nalbantoglu J. and Brodt P. Glioma cells with genetically engineered IGF-I Receptor downregulation can persist in the brain in a dormant state. Frontiers in Oncology, 2020 Sep 23; Vol.10, article 555945:1-12. doi: 10.3389/fonc.2020.555945. eCollection 2020.

Ìý³Õ²¹³ú²¹²Ô²¹ U., Schori L., Monsonego U., Swissa E., Pell G., Roth Y., Brodt P., Friedman A., and Prager O. TMS-induced controlled BBB opening: Pre-clinical characterization study and implications for brain cancer treatment. Pharmaceutics. 2020 Oct 5;12(10):946. doi: 10.3390/pharmaceutics12100946.

 Ciner A.T., Jones, K., Muschel R. and Brodt P. The unique immune microenvironment of liver metastases: Challenges and opportunities. Semin Cancer Biol. 2021 Jun;71:143-156. doi: 10.1016/j.semcancer.2020.06.003. Epub 2020 Jun 8 – invited review

Chen Y.M., Qi S., Perrino S., Hashimoto M., and Brodt P. Targeting the IGF-axis for cancer therapy: Development and validation of an IGF-Trap as a potential drug. Cells. 2020 Apr 29;9(5):1098. doi: 10.3390/cells9051098 –invited review

Qi S., Perrino S., Lamarche-Vane N. and Brodt P. The chemokine CCL7 regulates invadopodia maturation and MMP-9 mediated collagen degradation in liver-metastatic carcinoma cells. Cancer Lett. 2020 Jul 28;483:98-113. doi: 10.1016/j.canlet.2020.03.018. Epub 2020 Mar 23

Ma H.-Y, (+15 authors), Brodt, P., Mckillop I.H., Dennis E., Saltiel A., Tsukamoto H., Gao B., Karin M., Brenner D.A., and Kisseleva T. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 May;72(5):946-959. doi: 10.1016/j.jhep.2019.12.016. Epub 2019 Dec 31

Milette, S., Hashimoto, M., ±Êé°ù°ù¾±²Ô´Ç, S., Qi, S., Chen, M., Ham, B., Wang, N., Istomine, R., Lowy, AM., Piccirillo, °ä.Ìý²¹²Ô»å Brodt, P., Sexual Dimorphism and the Role of Estrogen in the Immune Microenvironment of Liver Metastases, Nat Commun. 2019 Dec 17;10(1):5745. doi: 10.1038/s41467-019-13571-x.

Vaniotis, G., Moffett, S., Sulea, T., Wang, N., Elahi, S.M., Lessard, E., Baardsnes, J., Perrino, S., Durocher, Y., Frystyk, J., Massie, B., and Brodt, P. Enhanced anti-metastatic bioactivity of an IGF-TRAP re-engineered to improve physicochemical properties, Sci Rep., 8(1):17361-17374, 2018, doi: 10.1038/s41598-018-35407-2.

Vaniotis, G., Rayes, RF., Qi, S., Milette, S., Wang, S., Perrino, S., Nyström, N., He, Y., Lamarche-Vane, N., and Brodt, P. Collagen IV-conveyed signals regulate cytokine production and promote liver metastasis, Oncogene, 37(28): 3790-3805, 2018,  doi: 10.1038/s41388-018-0242-z. Epub 2018 Apr 13.

Rayes, R., Fernandez, M.C., Milette, S., Wang, N., Bourdeau, F., Ham, B.,Yakar, S., and Brodt, P. Loss of neutrophil polarization in colon carcinoma liver metastases of mice with an inducible, liver-specific IGF-I deficiency, Oncotarget, 9(21):15691-15704, 2018, doi: 10.18632/oncotarget.24593. eCollection 2018 Mar 20.

Van Dam, P-J, Van der Stok, EP., (+ 27 authors), Brodt P., Reynolds AR and Vermeulen, PB. International consensus guidelines for scoring the histopathological growth patterns of liver metastasis- British Journal of Cancer, 117(10):1427-1441, 2017, doi: 10.1038/bjc.2017.334. Epub 2017 Oct 5.

Milette, S., Sicklick, J.K., Lowy, AM., and Brodt P., Molecular Pathways: Targeting the microenvironment of liver metastases. Clin. Cancer Research – 2017, doi: 10.1158/1078-0432.CCR-15-1636. Epub 2017 Jun 14. Review.

Fernandez, M.C., Rayes, R., Ham, B., Wang, N., Bourdeau, F., Xu, J., Kisselova, T. and Brodt, P. (2016). The type I Insulin-like growth factor regulates the liver stromal response to metastatic colon carcinoma cells. Oncotarget,8(32): 52281–52293, 2017, doi: 10.18632/oncotarget.12595. eCollection 2017 Aug 8. 

Brodt, P., Role of the microenvironment in liver metastasis: from pre- to prometastatic niches- Clinical Cancer Research -Invited review, 15;22(24): 5971-5982, 2016, Epub 2016 Oct 19. Review. 

Ham, B., Fernandez, M.C., D’Costa, Z. and Brodt, P. The diverse roles of the TNF axis in cancer progression and metastasis. Trends in Cancer Research - Invited Review, 11:1-27, 2016.

Ham, B., Wang, N., D’Costa, Z., Fernandez, M. C., Bourdeau, F., Auguste, P., Illemann, M., Eefsen, R.L., Høyer-Hansen, G., Vainer, B., Evrard, M., Gao, Z-H., and Brodt, P. TNF receptor-2 facilitates an immunosuppressive microenvironment in the liver to promote the colonization and growth of hepatic metastases. Cancer Research, 75(24):5235-47, 2015, doi: 10.1158/0008-5472.CAN-14-3173. Epub 2015 Oct 19.

Li, S., Pinard, M., Wang, Y., Yang, L., Lin, R., Hiscott, J., Su, B., and Brodt, P. Crosstalk between the TNF and IGF pathways enhances NF-κB activation and signaling in cancer cells. Growth Hormone IGF Research, 25(5): 253-261, 2015, doi: 10.1016/j.ghir.2015.07.008. Epub 2015 Jul 20.

Wang, N., Rayes, R.F., Elahi, S.M., Lu, Y., Hancock, M.A., Massie, B., Rowe, G.E., Aomari, H., Hossain, S., Durocher, Y., Pinard, M., Tabariès, S., Siegel, P.M., Brodt, P. The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis. Molecular Cancer Therapeutics, 14(4): 982 – 993, 2015, doi: 10.1158/1535-7163.MCT-14-0751. Epub 2015 Feb 11.

Haçariz O, Elucidation of IMP-1 inhibition in a pancreatic ductal organoid model through transcriptome profiling. Experimental Surgery Graduate Program Research day, 2023

Haçariz O, Messina-Pacheco J, Goodfellow E. Gregorieff A and Brodt P. Transcriptomic profiling of IMP-1 target genes reveals potential drivers of pancreatic ductal adenocarcinoma progression. CRP and Department of Oncology Research Day, 2023

Benslimane Y., Lapin S., Chambon J., Perrino S. and Brodt P. Estrogen regulates the immune microenvironment and immunotherapy response of colorectal liver metastases. Am. Assoc. Cancer Res, 2023

Benslimane Y, Lapin S. Perrino S. and Brodt P. Estrogen Regulates the Immune Microenvironment of Colorectal Cancer Liver Metastases, Am. Assoc. Cancer Res, 2022

Hamad A., Zhang H., Ejaz A., Huang H., Brodt P. and Tsung A. Is there a Role for Estrogen in the Prognosis of Patients Diagnosed with Colorectal Liver Metastases? American Surgical Congress, 2021

*Chen YM, Qi S, Hashimoto M, Perrino S, Jabado N, Brodt P. Evaluation of the IGF-Trap for the treatment of high-grade adult and pediatric glioma. Presented at: GH/IGF-1 action in health, disease, and aging virtual series. Abstract Collection published in Pituitary, 2020.

*Chen YM, Qi S, Hashimoto M, Perrino S, Jabado N, Brodt P. The IGF-Trap Inhibits the Growth of a Patient-Derived Pediatric High-Grade Glioma. Poster presented at: Vth International Drug Development and Discovery Forum; Montreal, Canada, (Winner of a best poster presentation prize), 2019.

*Chen M., Qi S., Hashimoto M., Perrino, S., Jabado N. and Brodt P., Evaluation of an IGF-Trap for the treatment of pediatric high-grade gliomas, Cancer Research Program Research Day, Montreal, Canada, 2019.

*Milette, S., Perrino, S., Wang, N., Piccirillo C., Lowy A. and Brodt P., Targeting the estrogen receptor axis to inhibit metastatic expansion of hormone-independent tumors in the liver. Cancer Research Program Research Day, Montreal, Canada, 2018..

Brodt P., Samani A.A., Zhu X. and Nalbamtoglu J. Glioma cells with downregulated IGF-IR expression can persist in the brain in a dormant state. Proc. AACR conference on Dormancy and Residual Disease- Montreal, Canada, 2018.

*Milette S, Perrino S., Wang N., Piccirillo C. and Brodt P. Estrogen promotes immune evasion in the liver to enhance metastatic expansion. Proc. AACR conference on Dormancy and Residual Disease, Montreal, Canada, 2018.

*Konda J.D., Hashimoto M., Zhang J., Fernandez M.C., Wang N., Perrino S., Montermini L., Rak J., Jean-Sebastien Pelletier, Andrew Lowy and Pnina Brodt. Pancreatic Ductal Adenocarcinoma-associated stellate cells promote a pro-metastatic microenvironment in the liver - Proc. Am. Assoc. Cancer Res., Chicago, United States, 2018.

Milette, S., Perrino, S., Wang, N., Brodt, P., Sex hormones regulate the immune microenvironment of liver metastases. Cell symposia: Human Immunity. Banff, Alberta, Canada, 2017.

Qi, S., Vaniotis, G., Wang, N., Brodt, P. CCL7 promotes cancer cell invasion by regulating invadopodia formation via CCR3 signaling. Cancer Research Program Research Day, Montreal, Canada, 2017.

Milette, S., Perrino, S., Wang, N., Brodt, P. The role of sex hormones in the response of the immune microenvironment to liver metastases. Cancer Research Program Research Day, Montreal, Canada, 2017.

Tsui, J., Vaniotis, G., Fernandez, MC., Brodt., P. Identification of resistance mechanisms to IGF-IR targeting in triple negative breast cancer. Proc. Am. Assoc. Cancer Res., 2017.

Milette, S., Wang, N., Perrino, S., Brodt, P. Sex disparity in the response of the immune microenvironment to colon cancer liver metastases. Proc. Am. Assoc. Cancer Res., 2017.

Fernandez, M.C. and Brodt, P. An IGF-Trap inhibits metastasis of pancreatic ductal adenocarcinoma. Proceedings of the Molecular Therapeutics of Cancer Research Society, Seattle, United States, 2016.

Ham, B., D’Costa, Z., Wang, N., Fernandez, MC., Bourdeau, F., Auguste, Brodt., P. Regulation of the immunosuppressive microenvironment of liver metastases by TNFR2. Proc. Special Conference of the EACR/AACR/SIC, Florence, Italy, 2015.

Fernandez, MC., Rayes, RF, Xu, J., Kisseleva T., Yakar, S., Brodt, P. The IGF axis regulates hepatic stellate cell recruitment and activation during colorectal carcinoma liver metastasis.Proc. Am. Assoc. Cancer Res., 2015.

Ham, B., Auguste, P., Evrard, M., Wang, N., Bourdeau, F. and Brodt, P. Identification of a bone marrow-derived MDSC subset that promotes the growth of colon carcinoma liver metastases. Proc. Am. Assoc. Cancer Res., 2014.

Rayes, R.F., Burnier, J.V., Wang, N. and Brodt, P. A distinct gene expression program induced by extracellular matrix type IV collagen promotes liver metastasis. Proc. Am. Assoc. Cancer Res., 2014.

Rayes, R.F., Burnier, J.V., Wang, N. and Brodt, P. Regulation of site-specific liver metastasis by collagen IV-conveyed signals. Canadian Cancer Research Conference, Toronto, 2013.

Wang, N., Rayes, R., Lu, Y., Elahi, M., Qayum, N., Hancock, M. A., Massie, B., Siegel, P. and Brodt, P. A novel IGF-trap inhibits the growth of metastases from different tumor types. Gordon conference on Insulin-Like Growth Factors in Physiology Disease, Ventura, CA, 2013.

Wang, N., Pinard, M., Lu, Y., Pilotte, A., Gilbert, R., Massie, B., and Brodt, P. Sustained production of a soluble IGF-I receptor by gutless adenovirus - transduced host cells protects from tumor growth in the liver. Proc. Am. Assoc. Cancer Res., 2013.

Qayum, N., Wang, N. and Brodt, P. Hepatic stellate cell activation is TNF receptor 2-dependent and required for angiogenesis and liver metstasis. Hallmarks of Cancer Cell Symposium, San Francisco, 2012.

Van den Eynden, G., Bird, N., Illemann, M., Eefsen, R.L., Brodt, P., Majeed, A.W., Høyer-Hansen, G. and Vermeulen, P.B. Identification and characterisation of histological growth patterns of liver metastases of colorectal cancer: the result of different tumor micro-environment interactions. Proc. Metastasis Res. Soc.- 2012.

Eefsen, R.L., Van den Eynden, G.G., Høyer-Hansen, G., Brodt, P., Laerum, O.D., Vermeulen, P.B., Christensen, I.J., Wettergren, A., Federspiel, B., Willemoe, G.L., Østerlind, K. and Illemann, M. Uniform growth pattern observed within chemonaïve patients with multiple liver metastases. Proc. Ketstone Symposium, Dublin, Ireland, 2012.

Ham, B., Auguste, P., Evrard, M., Wang, N., Lu, Y. and Brodt, P. TNF-receptor 2 plays a critical role in liver metastasis by regulating sinusoidal endothelial VCAM-1 expression, LY6G+ leukocyte recruitment and transendothelial migration. Proc. Am. Assoc. Cancer Res- 2012.

Eefsen, R.L., Van den Eynden, G.G., Brodt, P., Burnier, J., Høyer-Hansen, G., Ib Jarle, C., Metrakos, P., Laerum, O.D., Federspie, B., Willemoe, G., Østerlind, K. and Illemann, M. Growth patterns of liver metastases as compared to resected tumors of the same colorectal cancer patients. Proc. ASCO GI Symposium, San Francisco, 2012.

Wang, N., Pilotte, E., Mehdy, L., Lu, Y., Gilbert, R., Massie, B and Brodt, P. Developing an IGF–I receptor decoy as an anti-cancer drug. Proc. of the 5th China Medicinal Biotech Forum – 2011.

Vaniotis, G., Rayes, RF., Qi, S., Milette, S., Bourdeau, F., Wang, N., Perrino, S., Lamarche-Vane, N., Brodt, P. Collagen IV-conveyed signals regulate cytokine production and promote liver metastasis. Cancer Research Program Research Day, Montreal, Canada, 2017.

Seccarecia, E., Li, S. and Brodt, P. The role of IGF1 signaling in site-specific tumor metastasis: Regulating matrix metalloproteinase (MMP) expression. Proc. Am. Assoc. Cancer Res- 2011.

Wang, N., Spicer, J., Ferri, L. and Brodt, P. The TNF receptor 2 promotes liver metastasis by regulating the recruitment of host inflammatory cells. Proc. Am. Assoc. Cancer Res- 2011.

Wang, N., Spicer, J., Ferri, L. and Brodt, P. Distinct and gender-specific roles of the TNF receptors in liver metastasis. Proceedings of the 15th international meeting of the International Society for Cells of the Hepatic Sinusoids – 2010.

Li, S., Yang, L., Lin, R., Hiscott, J. and Brodt, P. Crosstalk between TNF-α-and IGF signalling increases IL-6 production and protects tumor cells from TNF-α-induced apoptosis in the liver. Proc. Am. Assoc. Cancer Res- 2010.

Li, S., Yang, L., Lin, R., Hiscott, J. and Brodt, P. Overexpression of the IGF-I receptor alters the metastatic properties of tumor cells by regulating of their cytokine profiles: role of NF-B signaling. Proc. Am. Assoc.Cancer Res- 2009.

Burnier, J.V., Wang, N., Anteca, E., Michel, R.P., Hassanain, M., Metrakos, P., Burnier, M.N., Gallinger, S. and Brodt, P. Collagen IV expression levels are a critical determinant of liver metastasis. Proc. Am. Assoc. Cancer Res- 2009.

Brodt, P. (Ed): Liver Metastasis: Biology and Clinical Management –Springer-Verlag Heidlberg, London, NY, 2011, ISBN: 978-94-007-0292-9.

Siegel PM, Nyström H. and Brodt P. The Tumor Microenvironment of Colorectal Liver Metastases: Molecular Mediators and Future Therapeutic Targets In: Contemporary Management of Metastatic Colorectal Cancer: A Precision Medicine Approach, 2022, Aslam E, and Pawlik T. Editors, Springer-Verlag.

Siegel PM, Nyström H. and Brodt P. The Tumor Microenvironment of Colorectal Liver Metastases: Molecular Mediators and Future Therapeutic Targets In: Contemporary Management of Metastatic Colorectal Cancer: A Precision Medicine Approach, 2022, Aslam E, and Pawlik T. Editors, Springer-Verlag - 2022

Spicer, J., Brodt, P. and Ferri, L. Role of inflammation in the early stages of liver metastasis. In: Liver metastasis: Biology and Clinical Management, Brodt P. (Ed), Springer, Heidelberg, London, NY, pp 155-186, 2011.

Li, S., Yakar, S. and Brodt, P. Role of the IGF- axis in liver metastasis: experimental and clinical evidence. In: Liver metastasis: Biology and Clinical Management, Brodt P. Editor, Springer Heidelberg, London, NY, pp. 233-272, 2011.

Burnier, J., Li, S. and Brodt, P. Role The role of the IGF Axis in human malignancy - Evidence from epidemiological studies and tissue analysis. In: Insulin Resistance and Cancer, Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications - Fantus G. (Ed). Springer NY- pp.213-242, 2011.

Brodt P. Role of the host inflammatory response in colon carcinoma initiation, progression and liver metastasis. In: Colon Cancer Liver Metastasis, Beauchemin N. and Huot J (Ed). Springer NY, pp. 289-319, 2010.