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C茅line Aguer - Assistant Professor

海角社区

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F-1033, University du Qu茅bec en Outaouais (office hours: Tuesdays, 9-12 am)
Phone: (819) 595-3900 ext. 2527

1E103, H么pital Montfort
Phone: (613) 746-4621 ext. 6047

celine.aguer [at] mcgill.ca

Dr. C茅line Aguer combines her expertise in exercise physiology and biochemistry to understand how muscle metabolic defects contribute to the development of insulin resistance and type 2 diabetes. The overarching goal of her research program is to better understand how some environmental factors such as exercise and environmental pollutants may alter skeletal muscle energy metabolism. She is using an integrated approach in the study of muscle metabolism and exercise physiology ranging from metabolic pathways at the cellular level to exercise physiology at the whole-body level. She is particularly interested in the cross-talk between muscle and different tissues (e.g. adipose tissue, pancreatic islets) in the development of type 2 diabetes.

Her research lab is located at the Institut du Savoir Montfort in Ottawa, ON. At 海角社区 she teaches physiology and she is the student academic advisor in the Med-P program, Outaouais campus.

Education:

Postdoctorate, Biochemistry, Faculty of Medicine, University of Ottawa, 2009-2013

Ph.D., Sciences chimique et biologique pour la Sant茅, Universit茅 Montpellier 1, France, 2008

M.Sc., Physiologie de l鈥檈xercice, Universit茅 du Sud Toulon-Var, France, 2005


List of recent publications (* indicates supervised students)

  1. C. Aguer, E. Loro, D. Di Raimondo. (2020) Editorial: The Role of Muscle Secretome in Health and Disease. Frontiers in Physiology. doi: 10.3389/fphys.2020.01101
  2. R. Al Batran, K. Gopal, M.E. Capozzi, J.J. Chahade, B. Saleme, S.A. Tabatabaei-Dakhili, A.A. Greenwell, J. Niu, M. Almutairi, N.J. Byrne, G. Masson, R, Kim, F. Eaton, E.E. Mulvihill, L. Garneau*, A.R. Masters, Z. Desta, C.A. Vel谩zquez-Mart铆nez, C. Aguer, P.A. Crawford, G. Sutendra, J.E. Campbell, J.R.B. Dyck, J.R. Ussher. (2020) Pimozide alleviates obesity-induced dysglycemia via inhibiting skeletal muscle ketone body oxidation. Cell Metabolism. S1550-4131(20)30132-7. doi: 10.1016/j.cmet.2020.03.
  3. L. Garneau*, S. A. Parsons, S. R. Smith, E. E. Mulvihill, L. M. Sparks$, C. Aguer$. $co-corresponding authors. (2020) Plasma Myokine Concentrations After Acute Exercise in Non-Obese and Obese Sedentary Women. Frontiers in Physiology. 11:18. doi:10.3389/fphys.2020.00018
  4. F. Ahmed*,$, L. Chehad茅*,$, L. Garneau*, A. Caron*, C. Aguer. $co-first authors. (2020) The effects of acute BPA exposure on skeletal muscle mitochondrial function and glucose metabolism. Mol Cell Endocr. 499:110580. doi:10.1016/j.mce.2019.110580
  5. K.A. Hutchinson, S. Mohammad, L. Garneau*, K. McInnis, C. Aguer, K.B. Adamo. (2019) Examination of the myokine response in pregnant and non-pregnant women following an acute bout of moderate-intensity walking. Frontiers in Physiology. 10:1188. doi:10.3389/fphys.2019.
  6. E. Gu茅rin, H. Jaafar*, L. Amrani*, D. Prud鈥檋omme, C. Aguer. (2019) Intervention strategies to prevent comorbid depression among individuals with type 2 diabetes: a scoping review. Frontiers in Public Health. 5:7-35. doi:10.3389/fpubh.2019.00035
  7. L. Garneau*, C. Aguer. (2019) Role of myokines in the development of muscle insulin resistance and related metabolic defects in type 2 diabetes. Diabetes and Metabolism. 45(6):505-516. doi:10.1016/j.diabet.2019.02.006
  8. L. Nadeau*, C. Aguer. (2019) Reply to 鈥淒iscussion of 鈥業nterleukin-15 as a myokine: mechanistic insight into its effect on skeletal muscle metabolism鈥� -- Interleukin-15 and interleukin-15R伪-dependent/-independent functions in human skeletal muscle are largely unknown鈥�. Applied Physiology, Nutrition, and Metabolism. 44(3):338-339. doi:10.1139/apnm-2018-0823
  9. C. Tremblay Lagani猫re*, L. Garneau*, J.F. Mauger*, V. Peshdary, E. Atlas, A.S. Nikolla*, N.A. Chapados, C. Aguer. (2019) Polychlorinated biphenyl 126 exposure in rats alters skeletal muscle mitochondrial function. Environ Sci Pollut Res. 26(3):2375-2386. doi:10.1007/s11356-018-3738-8
  10. L. Nadeau*, D.A. Patten, A. Caron*, L. Garneau*, E. Pineault-Masson*, M. Foretz, P. Haddad*, B.G. Anderson, L. Quinn, M.-E. Harper, C. Aguer. (2019) IL-15 improves skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation. BBA General Subject. 1863:395-407. doi:10.1016/j.bbagen.2018.10.
  11. L. Nadeau*, C. Aguer. (2019) Interleukin-15 as a myokine: mechanistic insights into its effects on skeletal muscle metabolism. Invited review in Applied Physiology, Nutrition, and Metabolism. 44(3):229-238. doi:10.1139/apnm-2018-
  12. C. Dub茅, C. Aguer, K. Adamo, S. Bainbridge. (2017) A role for maternally derived myokines to optimize placental function and fetal growth across gestation. Applied Physiology, Nutrition, and Metabolism, 42(5):459-469. doi:10.1139/apnm-2016-0446
  13. D.P. Blondin, A. Daoud*, T. Taylor, H. Tingelstad, V.B茅zaire, D. Richard, A.C. Carpentier, A.W. Taylor, M.-E. Harper, C. Aguer$, F. Haman$. $co-corresponding authors. (2017) Four-weeks of cold acclimation in adult humans shifts the ATPase-independent source of heat production from skeletal muscle to BAT. J Physiol, 595(6):2099-2113. doi:10.1113/JP273395
  14. L. Chehad茅*,$, A. Caron*,$, C. Aguer. $co-first authors. (2016) Role of Environmental Pollutants in Skeletal Muscle Insulin Resistance and Mitochondrial Dysfunction. Invited review in Environment and Natural Resources Research, 6(4): 60-78. 10.5539/enrr.v6n4p60
  15. J.-F. Mauger*,$, L. Nadeau*,$, A. Caron*, N. Ann Chapados, C. Aguer. $co-first authors. (2016) Polychlorinated biphenyl 126 exposure in vitro in L6 myotubes alters glucose metabolism: a pilot study. Environ Sci Pollut Res, 23(8):8133-40. doi:10.1007/s11356-016-6348-3

Full list of publications:听

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